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CA-125 is made by cells in the female reproductive system, and by other cells in the body, and elevated levels of this protein can be a sign of certain medical conditions. The CA-125 blood test is most commonly used to monitor the progression of ovarian cancer, as elevated levels of CA-125 can be an indicator of the disease or its recurrence. The presence of high levels of CA-125 can be caused by other conditions, like endometriosis, uterine fibroids, and pelvic inflammatory disease. This makes the CA-125 blood test an important tool for diagnosing and monitoring a variety of medical conditions.